## Synchrotron imaging for validation and prediction models of diffusion MRI
**X-ray synchrotron imaging** uses a large-scale synchrotron research facility that basically can be seen as a gigantic nano-scope to create unique 3D images of intact tissue samples. There exist different synchrotron facilities in the world and we mostly use the MAXIV in Sweden, the ESRF in France, and the Swiss Light Source (SLS) in Switzerland etc.. Each synchrotron facility has different beamlines with highly specialized experimental setups, some of which allow us to observe anatomical features with nanometer resolution. As an example, we use phase-contrast imaging to map 3D anatomical morphology and architecture of axons, their myelin, and cell bodies, as well as the effects of pathology. We develop methods to segment, analyze and quantify 3D morphology and architecture features from synchrotron images. These are used for the prediction and validation of microstructural estimates obtained from the low-image resolution MRI scannings i.e., diffusion MRI.
X-ray synchrotron imaging uses a large-scale synchrotron research facility that basically can be seen as a gigantic nano-scope to create unique 3D images of intact tissue samples. There exist different synchrotron facilities in the world and we mostly use the MAXIV in Sweden, the ESRF in France, and the Swiss Light Source (SLS) in Switzerland etc.. Each synchrotron facility has different beamlines with highly specialized experimental setups, some of which allow us to observe anatomical features with nanometer resolution. As an example, we use phase-contrast imaging to map 3D anatomical morphology and architecture of axons, their myelin, and cell bodies, as well as the effects of pathology. We develop methods to segment, analyze and quantify 3D morphology and architecture features from synchrotron images. These are used for the prediction and validation of microstructural estimates obtained from the low-image resolution MRI scannings i.e., diffusion MRI.
